Serogem-250 Gencaps – Salmeterol & Fluticasone Propionate Powder for Inhalation IP – is a fixed-dose combination therapy designed for the long-term management of asthma and chronic obstructive pulmonary disease (COPD). It contains Salmeterol, a long-acting beta-2 agonist (LABA), and Fluticasone Propionate, an inhaled corticosteroid (ICS), working together to relax airway muscles and reduce inflammation in the lungs. This dual mechanism of action helps keep the airways open, reduces flare-ups, and improves breathing comfort over time. It is especially beneficial for patients whose symptoms are not adequately controlled with inhaled corticosteroids alone.

Administered through a dry powder inhaler, Serogem-250 Gencaps delivers targeted treatment directly to the lungs with minimal systemic absorption, ensuring both safety and efficacy. Though some improvement may be noticed within a few days of use, full therapeutic benefits are generally seen after regular, consistent use over several weeks. Importantly, this medication is meant for preventive maintenance and is not intended for sudden asthma attacks. Patients should continue therapy even when symptoms improve, as stopping it abruptly can worsen respiratory conditions.

To maximize its effect, it’s essential to use the inhaler correctly. Poor inhalation technique may result in inadequate dosing and reduced benefit. Patients are advised to follow their doctor’s instructions closely regarding dosage and frequency and to always keep a quick-relief inhaler on hand for emergencies. Regular use of Serogem-250 Gencaps can significantly improve lung function, symptom control, and overall quality of life in patients with chronic airway diseases.

Key Features of Serogem-250 Gencaps – Salmeterol & Fluticasone Propionate Powder for inhalation IP:

• Dual-Action Combination Therapy: Combines a long-acting bronchodilator (Salmeterol) and a corticosteroid (Fluticasone) for effective airway management.
• Dry Powder Inhaler (DPI) Technology: Ensures direct, targeted drug delivery to the lungs with minimal systemic exposure.
• Long-Lasting Relief: Provides up to 12 hours of symptom control, helping patients breathe more comfortably throughout the day and night.
• Maintenance Therapy: Designed for regular, long-term use to prevent symptoms and exacerbations—not intended for sudden asthma attacks.
• Fast-Acting Onset: Begins to ease breathing within minutes of inhalation while maintaining long-term airway stability.
• Relieves Multiple Respiratory Symptoms: Effectively reduces chest tightness, shortness of breath, wheezing, and coughing.
• Improves Quality of Life: Supports easier breathing and enhanced physical activity in patients with asthma and COPD.
• Clinically Proven & Safe: Backed by evidence and trusted for its safety and effectiveness when used as prescribed.
• User-Friendly Device: Convenient, easy-to-use inhaler promotes better compliance and proper dosage delivery.
• Trusted Brand Assurance: Manufactured by Genetic Pharma, known for its quality, innovation, and affordability.

 Indications for Serogem-250 Gencaps – Salmeterol & Fluticasone Propionate Powder for inhalation IP:

• Asthma: For patients not adequately controlled with inhaled corticosteroids alone.
• COPD: For patients with frequent symptoms and a history of exacerbations, especially those with chronic bronchitis.

 Dosage And Administration:

Strengths Available:

• 100/50 mcg
• 250/50 mcg 
• 500/50 mcg
  (Fluticasone Propionate / Salmeterol)

Route of Administration:

• Inhalation only 
• Recommended Dosage: Twice daily (one inhalation in the morning and one in the evening)

Administration Instructions:

• Use only with a suitable dry powder inhalation device such as a Rotahaler or Accuhaler, as prescribed by your healthcare provider.
• Do not swallow the capsules (Rotacaps). These are strictly for inhalation use.
• To use a Rotahaler:
• Place the capsule at the base of the inhaler, not in the mouthpiece.
• Twist the mouthpiece completely until you hear a click—this pierces the capsule.
• Exhale fully, then breathe in deeply and forcefully through the mouthpiece.
• Hold your breath for about 10 seconds, or as long as comfortable, to allow the medicine to settle in the lungs.
• If powder remains in the capsule, repeat the inhalation process to ensure complete dosage.
• Rinse your mouth thoroughly with water after each dose to prevent the risk of oral thrush (fungal infection).
• Do not use this medication to relieve sudden breathing problems. In such cases, use a quick-relief (rescue) inhaler as directed by your physician.

Note: Check the label for directions before use.

Precautions:

• Not a Rescue Inhaler: Serogem-250 Gencaps is not intended for the treatment of acute bronchospasm or sudden asthma attacks. Always keep a short-acting rescue inhaler available for emergencies.
• Use with Caution In:

• Patients with cardiovascular disorders such as hypertension or arrhythmias

   

• Individuals with diabetes mellitus, as corticosteroids may elevate blood glucose levels

   

• Those with thyroid dysfunction, especially hyperthyroidism

   

• Patients with severe hepatic impairment, due to potential changes in drug metabolism

• Adrenal Suppression: Long-term use of inhaled corticosteroids may suppress adrenal gland function. Regular monitoring is advised in patients on prolonged therapy.
• Pediatric Use: Not recommended in children under 4 years of age unless specifically advised by a healthcare provider, as safety and efficacy may vary with age and formulation.
• Alcohol Consumption: The interaction of Serogem-250 Gencaps with alcohol is not well established. Consult your doctor before consuming alcohol while on this medication.
• Pregnancy: Use with caution. There is limited data in humans, but animal studies suggest potential risk to the developing fetus. This medication should only be used during pregnancy if clearly needed and prescribed by a doctor.
• Breastfeeding: The safety of Serogem-250 Gencaps during lactation is not well established. Please consult your doctor before use if you are breastfeeding.

   Note: Consult your healthcare provider 

Side Effects:

Like all medications, Serogem-250 Gencaps (Salmeterol & Fluticasone Propionate Powder for Inhalation IP) may cause side effects, although not everyone experiences them. Most side effects are mild and tend to go away as your body adjusts to the medicine. However, if any symptoms persist or worsen, you should consult your doctor.

Common Side Effects:

• Hoarseness or voice changes
• Oral thrush (fungal infection in the mouth and throat)
• Cough or throat irritation
• Headache
• Dryness in the mouth
• Stomach discomfort
• Upper respiratory tract infections
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Sinus inflammation

Less Common Side Effects:

• Palpitations
• Muscle cramps
• Increased heart rate (tachycardia)
• Tremors or shakiness
• Elevated blood sugar levels (hyperglycemia)
• Aggressive or unusual behavior (especially in children)

Serious (Rare) Side Effects:

• Paradoxical bronchospasm (sudden worsening of breathing symptoms after inhalation)
• Adrenal suppression with long-term use
• Allergic reactions such as skin rash, itching, swelling of the face, lips, or tongue

Note: Consult your healthcare provider  

How to Store Serogem-250 Gencaps – Salmeterol & Fluticasone Propionate Powder for inhalation IP:

• Store below 30°C

 Why Choose Serogem-250 Gencaps – Salmeterol & Fluticasone Propionate Powder for inhalation IP From Genetic Pharma?

Serogem-250 Gencaps offers a clinically proven, reliable solution for the maintenance treatment of asthma and COPD, crafted with a focus on efficacy, safety, and patient convenience. Manufactured by Genetic Pharma, a trusted name in pharmaceutical innovation, Serogem-250 Gencaps combines high-quality active ingredients with advanced dry powder inhalation technology to ensure optimal drug delivery directly to the lungs.

What sets Serogem-250 Gencaps apart is the precision formulation of Fluticasone Propionate 250 mcg and Salmeterol 50 mcg, providing both anti-inflammatory and long-acting bronchodilator effects. This dual-action therapy helps in reducing airway inflammation, preventing bronchospasm, and improving long-term lung function. Genetic Pharma uses cutting-edge Rotacap technology to maintain the integrity and stability of the drug, ensuring consistent dosage and rapid onset of action.

Backed by stringent quality control, affordable pricing, and user-friendly packaging, Serogem-250 is designed to support better patient compliance and satisfaction. Whether for newly diagnosed cases or patients with moderate-to-severe respiratory conditions, Serogem-250 Gencaps stands as a reliable, effective, and economical choice for healthcare providers and patients alike.